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Abudayyeh-Gootenberg Lab

Building and applying the next generation of molecular tools


Progress in science depends on new techniques, new discoveries and new ideas, probably in that order.
– Sydney Brenner

The AbuGoot lab combines natural biological discovery and molecular engineering to develop a suite of new tools for manipulation of DNA, RNA, and cellular states – the cellular engineering toolbox. These tools have the ability to push our understanding of complex systems, provide novel diagnostic insights, and enable new platforms of therapeutics. We are enthusiastic about applying these tools to multiple areas, including cellular fate, aging, and genetic disease.

Latest Publications

Programmable RNA-guided endonucleases are widespread in eukaryotes and their viruses


Jun 14, 2023

A Transcription Factor Atlas of Directed Differentiation


Jan 5, 2023

Drag-and-drop genome insertion without DNA cleavage with CRISPR-directed integrases.

Nature Biotechnology

Nov 24, 2022

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