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Abudayyeh-Gootenberg Lab

Building and applying the next generation of molecular tools


"Progress in science depends on new techniques, new discoveries and new ideas, probably in that order."
– Sydney Brenner

The AbuGoot lab combines natural biological discovery and molecular engineering to develop a suite of new tools for manipulation of DNA, RNA, and cellular states – the cellular engineering toolbox. These tools have the ability to push our understanding of complex systems, provide novel diagnostic insights, and enable new platforms of therapeutics. We are enthusiastic about applying these tools to multiple areas, including cellular fate, aging, and genetic disease.

Latest Publications

Programmable RNA writing with trans-splicing


Feb 1, 2024

Advances in genome, epigenome, and transcriptome editing using CRISPR effectors,

Nature Reviews Molecular Cell Biology

Nov 1, 2023

Programmable RNA-guided DNA endonucleases are widespread in eukaryotes and their viruses

Science Advances

Sep 27, 2023

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